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The BAPTA and its derivatives was synthesized successfully

The BAPTA and its derivatives was synthesized successfully

The invetion discloses stable diesters of chelating agents of divalent metal ions,processes for their preparation and pharmaceutical compositions thereof. Most preferred compounds according to the present invention are atable lipophilic diesters comprising a covalent conjuagate of a BAPTA and a pharmaceutically acceptable alcohol.The diesters are useful in a method for treationg a condition or disease related to an excess of divalent metal ions, and in particular for the treatment of a condition or disease related to elevated levels of intracellular calcium ions,such as in brain or cardiac ischemia,stroke,epilepsy,Alzheimer's disease or cardiac arrhythmia and in open heart surgery

 
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