User Login
  • sign in with your pharmablock
  • E_Mail£º   
  • Password£º 
  Contact US
  • E-mail
  • Manager Mr. Zhuang
  • TEL +86 021-60499358
  • FAX +86 021-51069359
  • MOB +86 (0)13661956116
  • Website
  • Address Shanghai, China Guiping Road 333, 200237
Adrenoceptor and Tetrabenazine Antagonism Activities of Some

A series of pyridinyltetrahydropyridine derivatives was synthesized and evaluated as adrenoceptor and tetrabenazine
antagonists. 4-(3-Fluoro-2-pyridinyl)-1,2,5,6-tetrahydropyridpinroev ed to be the most potent and selective c y p -
adrenoceptor antagonist of the series as measured in vitro by displacement of [3H]clonidine and [3H]prazosin from
membrane binding sites of calf cerebral cortex and by antagonism of the effects of clonidine and methoxamine in
the rat isolated, field-stimulated vas deferens. In addition, this compound, and the corresponding desfluoro derivative,
blocked tetrabenazine-induced ptosis in the mouse.